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KMID : 1132720130110010038
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Genomics & Informatics
2013 Volume.11 No. 1 p.38 ~ p.45
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Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis
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Lee Kye-Hwa
Lim Jae-Hyeun
Kim Ju-Han
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Abstract
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In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.
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KEYWORD
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acute myeloid leukemia, biolattice, concept lattice analysis, DNA mutational analysis, DNA sequence analysis, oncogenes
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